Introduction the speakers at Epigenetic Symposium

Marisa S. Bartolomei

the Perelman Professor of Cell and Developmental Biology and Co-Director of the Epigenetics Institute at Upenn

• Research interest: genomic imprinting and X inactivation in mice
• Contribution shortlists in genomic imprinting
  • identified H19, Igf2 and related diseases
  • identified regulation mechanism via ICR
  • DNA methylation in conferring the parental identity of imprinted genes
• Recent updates
  • epigenetic dysregulation mechanism and outcomes (e.g. Rhon-Calderon et al., 2024), (Prasasya et al., 2024).
  • DNA methylation profiling method development (e.g. Lee et al., 2024).

Isabelle Mansuy

Professor in Neuroepigenetics at UZH and ETHZ

• Research interest: epigenetic factors and chromatin organization and transmission of modified traits
• Contribution shortlist in molecular mechanisms of memory:
  • role of PP1 and calcineurin
  • epigenetic basis as a inheritable “memory”
• Recent updates
  • science in all rounds of epigenetic factors and chromatin states (e.g. Otaru et al., 2024), (LaPlante et al., 2023).
  • social relevance on epigenetics (e.g. Dalpé et al., 2024).

Anita Öst

Head of division of CNB at LiU

• Research interest: link through early life experience, spermatogensis, embryo development, and offspring health
• Contribution shortlist in fetal programming:
  • reprogramming of adipocytes in T1D patients
• Recent updates
  • small RNAs (e.g. Skog et al., 2023).
  • response to diet (e.g. Dalpé et al., 2024 , Ramesh et al., 2023).

Antoine Peters

Group Leader at FMI

• Research interest: epigenetic regulators in stem cell (pre-implantation embryos) properties
• Contribution shortlist in epigenetic regulators, especially histone markers:
  • LSD1, Suv39h
  • histone markers in cellular plasticity
• Recent updates, see google scholar
  • germs cells
  • early embryogenesis

James Hackett

Group Leader at EBML

• Current research interest: epigenetic reprogramming in germline cells
• Contribution shortlist in mechanisms of (interplay of) 5mC, 5hmC and histone markers:
• Recent updates
  • perturbation of cis-regulating elements
  • ‘gut-male germline-placenta axis’

Gavin Kelsey

Head of epigenetic program at Brabaham Institute

• Current research interest: from epigenetic states in oocyte to embryo
• Contribution shortlist:
  • placenta specific imprinting: IGF-II, Gnas
  • from scGBS to scNMT
• Recent updates in oocyte growth, see google scholar

Ida Marie Astad Jentoft

Postdoc at MPI

Current research: dormancy and proteome regulation

• Recent updates:
  • Intracellular molecular mechanisms of oocyte (Jentoft, et al., 2023) and zygote (Scheffler, et al., 2023).

Bas Heijmans

Professor at Leiden University Medical Center

• Current research interest: from epigenetic states in oocyte to embryo
• Contribution shortlist:
  • epigenetics in prenatal famine
  • cis- and trans-eEQTL studies
  • epigenetics in aging
• Recent updates in interplay between metabolism and epigenetics; fetal growth restriction outcomes see google scholar

Vicente Perez Garcia

Researcher at University of Cambridge

• Current research interest: trophoblast differentiation and invasiveness
• Contribution shortlist:
  • placenta defects are highly prevalent in embryonic lethal mouse mutants
• Recent updates in epigenetic regulators of trophoblast function and knockout in mTSC see google scholar

Yuta Takahashi

Principal Investigator at Kumamoto University

• Research interest: Transgenerational epigenetic inheritance in mammals
• Contribution shortlist:
  • epigenetic mark arginine methylation regulates the lifespan of the nematode
  • introduction of CpG-free DNA into targeted CpG islands triggers de novo methylation of CpG islands in human PSCs
• Recent updates
  • transgenerational inheritance in mouse model with epigenetically modified DNA methylation(Takahashi et al., 2023)

• Previous
  AE PCOS 2024
• Next
  Life after life