Hong Jiang

I like creativity and innovation more than discovery.

I am good at characterizing biological system with omics and multi-layer molecular mechanisms. (with prior/relation to medical impacts).

theoretical biology, evolution, synthetic biology, and simulation are the four fields that never cease to allure me.

​being open and resilience, and live with the flow of science life cycle, better to move a bit before it.

EDUCATION

MOTIVATION

Integrate multi-omics data to model molecular and cellular processes and unravel the mechanisms of intergenerational inheritance

RESEARCH EXPERIENCES

PhD. Projects, KI 2021.11-Expected 2025.11

Supervisor: AP. Qiaolin Deng, AP. Claudia Kutter and Prof. Elisabet Stener-Victorin

• Revealing cell type-specific transcriptional signatures of the placenta in disease
• Meta-analysis, databases and web interfaces of placental transcriptomics in physiological conditions
• Metrics to compare comparisons
• Proposed ridge regression for ligand receptor inferences in a niche
• Infrastructure and data process management; working with high performance clusters

Visiting PhD. Projects, Helmholtz Munich 2025.08 – 2025.11

Supervisor: Carsten Marr

• Fine-tuning a Perceiver aggregator and a MIL for classifying whole slide images of cutaneous squamous cell carcinoma and basal cell carcinoma

Collaborative Projects

• Single-cell and spatial profiling of novel drug effects on colon of ulcerative colitis mouse model and human patients
• Single-cell RNA profiling of photodynamics treatment of pigmented villonodular synovitis
• Proteomics of photodynamics treatment of squamous-cell carcinoma mouse model
• Single-cell and spatial profiling of WFS1-deficient mouse brain to validate neurodegenerative hypothesis
• Brouillon microscopy imaging analysis, specifically, cell segmentation
• Molecular design of compound 16a as a novel TGFβR1 inhibitor.

Bioinformatician, KeyMed 2018.3-2018.9

• Preclinical validation of drug targets.

Msc. Projects, USTC | Supervisor: Prof. Xiaoyuan Song and Prof. Lau Pak-Ming 2018.9- 2021.6

• Characterize and classify patterns of chromatin topological structures and relate to other epigenetic, gene expression and cellular processes.
• Data mining for building a piRNA-Cancer database.

Undergraduate Thesis, USTC | Supervisor: Prof. Qinghua Shi and Prof. Xiaoyuan Song2018.2-2018.6

• Construct a pipeline for C. elegans WGS data analysis and found causal genes for specific phenotype using statistical testing.

Intern, NJU | Supervisor: Prof. Yi Cao 2017.3-2017.10

• Synthesize and test the physical properties of slow-released PEG hydrogel with different ratio of β − diacerein.

Project for talent training plan, CPU ｜Supervisor: Prof. Min Wang and Chen Luo 2017.9-2017.12

• Investigate the therapeutic effects of protein Regeneration2 on type 2 diabetes.
• Analyze the components from sealing rubber contacted water using LC-MS.

PUBLICATIONS

1. Zhao, Allan, Hong Jiang, Arturo Reyes Palomares, Alice Larsson, Wenteng He, Jacob Grünler, Xiaowei Zheng, Kenny A Rodriguez Wallberg, Sergiu-Bogdan Catrina, and Qiaolin Deng. “Appropriate Glycemic Management Protects the Germline but Not the Uterine Environment in Hyperglycemia.” EMBO Reports 25, no. 4 (March 15, 2024): 1752–72..
2. Derisoud, Emilie#, Hong Jiang#, Allan Zhao, Pascale Chavatte-Palmer, and Qiaolin Deng. “Revealing the Molecular Landscape of Human Placenta: A Systematic Review and Meta-Analysis of Single-Cell RNA Sequencing Studies.” Human Reproduction Update 30, no. 4 (July 1, 2024): 410–41..
3. Lu, Haojiang#, Hong Jiang, # Congru Li#, Emilie Derisoud, Allan Zhao, Gustaw Eriksson, Eva Lindgren, et al. “Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming,” December 12, 2023..
4. Pei, Yu#, Sanjiv Risal#, Hong Jiang, Haojiang Lu, Eva Lindgren, Elisabet Stener-Victorin, and Qiaolin Deng. “Transcriptomic Survey of Key Reproductive and Metabolic Tissues in Mouse Models of Polycystic Ovary Syndrome.” Communications Biology 6, no. 1 (January 18, 2023): 69..
5. Luo, Zhengyu#, Xiaorong Wang#, Hong Jiang#, Ruoyu Wang, Jian Chen, Yusheng Chen, Qianlan Xu, et al. “Reorganized 3D Genome Structures Support Transcriptional Regulation in Mouse Spermatogenesis.” iScience 23, no. 4 (April 2020): 101034..
6. Luo, Zhengyu#, Tengfei Hu#, Hong Jiang, Ruoyu Wang, Qianlan Xu, Simo Zhang, Jun Cao, and Xiaoyuan Song. “Rearrangement of Macronucleus Chromosomes Correspond to TAD-like Structures of Micronucleus Chromosomes in Tetrahymena Thermophila.” Genome Research 30, no. 3 (March 2020): 406–14..
7. Cao, Jun#, Hong Jiang#, Ran Zhang, Amr.R. Ghanam, Honghai Xia, Yuting Zhu, Zhen Yang, and Xiaoyuan Song. “Epigenomic Profiling Identifies the Role of Nr5a2 and CYP1B1 in Hepatocellular Carcinoma Stemness Maintenance.” Science Bulletin 64, no. 16 (August 2019): [1132–35.] (https://doi.org/10.1016/j.scib.2019.06.017).
8. Muhammad, Azhar, Ramay Waheed, Nauman Ali Khan, Hong Jiang, and Xiaoyuan Song. “piRDisease v1.0: A Manually Curated Database for piRNA Associated Diseases.” Database 2019 (January 1, 2019): baz052..

DATASETS

1. Hong, Jiang. “Integrated and Annotated Human Placenta scRNA-Seq Matrices.” Zenodo, May 2, 2024..
2. Hong, Jiang, and Song Xiaoyuan. “Subtypes of Chromatin Topologically Associated Domains in Mouse Embryonic Stem Cell.” Zenodo, 2024..

CONFERENCE&GRANT

1. Travel grant from International Society for Computational Biology for presenting at European Conference of Computational Biology 2024
2. DMM conference travel grant for presenting at European Placenta Group 2024
3. Attending the scverse Conference 2024
4. Presenting at the Society for the Study of Reproduction conference 2024
5. Svenska Sällskapet för Medicinsk Forskning travel grant for visiting research project at HelmHoltz